Computational and Disease Genomics Lab

Our lab is focused on developing and applying robust bioinformatics methods to large-scale, high-throughput, multi-dimensional Genomics, Epigenomics, and Transcriptomics data with the main emphasis on elucidating and understanding human disease progression and development, which is further expected to translate to public health practice.

Recent News

May 24th, 2025

New Paper (Nature Communications)

Congratulations that our collaborative work with Dr. Mireya Plass has been accepted in principle by Nature Communications. Our study reveals a novel computational method SCALPEL that can accurately quantification of transcript isoforms at the single-cell level.

March 31th, 2025

Michael Snyder Visit to Our Lab

Professor Michael Snyder, Chair of the Department of Genetics at Stanford University School of Medicine, visited our Lab and delivered a great presentation about precision medicine. Prof. Snyder also had a nice discussions with our lab trainees.

February 28th, 2025

Third Faculty from Our Lab

Congratulations to our trainee, Dr. Zeyang Wang, starting his independent lab as an Associate Professor at China Medical University! He is the third independent faculty member from our lab. Cheers!

February 20th, 2025

New Paper (Molecular Cell)

Congratulations that our collaborative work with Dr. Yongsheng Shi has been accepted in principle by Molecular Cell. Our study reveals a novel "nuclear RNA degradation code" that triggers PAXT-mediated RNA decay.

January 31th, 2025

New Paper (Adv. Sci.)

Our genetic basis of enhancer RNAs paper has finally been accepted by Advanced Science. We constructed a comprehensive atlas of eRNA-mediated genetic effects in 49 human normal tissues and 31 tumor types, revealing a distinctive class of pan-cancer susceptibility eRNAs. Congratulations to Wenyan, Zeyang and Yinuo and many co-authors in the lab.

January 30th, 2025

New Paper (Nature)

Congratulations that our collaborative work with Dr. Ruan Wei, Dr Eltzschig has been accepted by Nature. Our study demonstrates that the BMAL1/HIF2A heterodimer plays a crucial role in modulating the circadian variations of myocardial injury. Cheers.

January 22th, 2025

Director’s Scholarship

Congratulations to our graduate student, Hui, for receiving the prestigious Shenzhen Bay Laboratory Director’s Scholarship this year. We are honored that our lab has been recognized with this award for three consecutive years.

December 26th, 2024

New Faculty Appointments

Congratulations to our two trainees, Dr. Wenyan Chen and Dr. Ruofan Ding, on their new faculty positions at Inner Mongolia University and Huizhou University, respectively.

November 26th, 2024

New Paper (Nat. Commun.)

Our alternative polyadenylation outliers (aOutliers) paper has finally been accepted by Nature Communications. We conducted a comprehensive cross-tissue analysis of aOutliers and discovered a unique class of aOutliers-associated RVs with a large effect on disease. Congratulations to Xudong.