Welcome to the Cancer GWAS database (TCGD)


TCGD is a database of publicly available Cancer GWAS summary statistics. Each GWAS can be browsed with the manhattan plot, risk loci, SNP heritability and genetic correlations with other GWAS in the database.

Cancer GWAS were performed in this project based on (1) integrated the GWAS summary statistics reported in the published (including NHGRI EBI GWAS Catalog, GWAS ATLAS, Japanese ENcyclopedia of GEnetic associations by Riken /JENGER, and PUBMED); (2) publicly available GWAS summary statistics of the UK Biobank Imputed Dataset (v3); and (3) combining genome information with digital health care data from national health registries of the FinnGen data (see Web Resources).



Currently the database contains 55 Cancer GWAS from 55 unique studies across 22 cancer types.



Browse GWAS

Overview of each GWAS such as Manhattan plots and QQ plot at SNP and gene levels and genetic correlations with other GWAS in the database.


Colocalization

Overview of each significant genetic risk loci from different cancer GWAS.



Browse TWAS

Overview of each significant genetic risk loci from different cancer GWAS.



What's new

2023-12-11
We add a search bar used for retriving database by gene name or cancer type, a help document for providing guidance, and provide all GWAS, TWAS and colocalization data in download page. These modification will help user use our database more conveniently.
2023-08-09
Third release of TCGD database with TWAS and colocalization results of TCGA cohort data.
2023-02-14
Second release of atlas database with in total of 80 GWAS summary statistics. The last database curation was done in Feb 2023.
2023-02-03
We updated the TWAS results in 23 main cancer types identifing candidate susceptibility genes.
2022-08-15
We updated the colocalization results and 3’aTWAS models for GTEx v8.
2021-10-17
We have added a page to report missing GWAS from the TCGD database. We appreciate any contribution.
2021-07-13
First release of the Cancer GAWS database(TCGD) with 397 GWAS summary statistics. The last database curation was done in January 2021. We will update summary statistics published since then, in near future. Publication is under preparation.
2020-10-18
First internal release of the website.