Computational and Disease Genomics Lab

Our lab is focused on developing and applying robust bioinformatics methods to large-scale，high-throughput, multi-dimensional Genomics, Epigenomics, and Transcriptomics data with the main emphasis on elucidating and understanding human disease progression and development, which is further expected to translate to public health practice.

Recent News

February 20th, 2025

New Paper (Molecular Cell)

Congratulations that our collaborative work with Dr. Yongsheng Shi has been accepted in principle by Molecular Cell. Our study reveals a novel "nuclear RNA degradation code" that triggers PAXT-mediated RNA decay.

January 31th, 2025

New Paper (Adv. Sci.)

Our genetic basis of enhancer RNAs paper has finally been accepted by Advanced Science. We constructed a comprehensive atlas of eRNA-mediated genetic effects in 49 human normal tissues and 31 tumor types, revealing a distinctive class of pan-cancer susceptibility eRNAs. Congratulations to Wenyan, Zeyang and Yinuo and many co-authors in the lab.

January 30th, 2025

New Paper (Nature)

Congratulations that our collaborative work with Dr. Ruan Wei, Dr Eltzschig has been accepted by Nature. Our study demonstrates that the BMAL1/HIF2A heterodimer plays a crucial role in modulating the circadian variations of myocardial injury. Cheers.

January 22th, 2025

Director’s Scholarship

Congratulations to our graduate student, Hui, for receiving the prestigious Shenzhen Bay Laboratory Director’s Scholarship this year. We are honored that our lab has been recognized with this award for three consecutive years.

December 26th, 2024

New Faculty Appointments

Congratulations to our two trainees, Dr. Wenyan Chen and Dr. Ruofan Ding, on their new faculty positions at Inner Mongolia University and Huizhou University, respectively.

November 26th, 2024

New Paper (Nat. Commun.)

Our alternative polyadenylation outliers (aOutliers) paper has finally been accepted by Nature Communications. We conducted a comprehensive cross-tissue analysis of aOutliers and discovered a unique class of aOutliers-associated RVs with a large effect on disease. Congratulations to Xudong.

August 23th, 2024

New Grant

Congratulations to Dr. Ruofan Ding in our team for receiving the Young Scientists Grant of the National Natural Science Foundation of China. This grant will support him to develop computational method for single cell sequencing data.

August 16th, 2024

2024 ASHG Trainee Research Excellence Award

Congratulations to our student Hui, who has received the Prestigious 2024 predoctoral Trainee Research Excellence Award. Also, Xudong has received the Reviewers’ Choice Award as his abstract ranked within the top 10% of all abstracts. Cheers!

July 31st, 2024

2024 ASHG Annual Meeting Oral Talk

Hui’s abstract has been ACCEPTED as a oral presentation at the ASHG 2024 Annual Meeting. There are less than 10% of abstracts can be selected as oral presentations. Cheers!