Shenzhen Bay Laboratory

Computational and Disease Genomics Lab

Our lab is focused on developing and applying robust bioinformatics methods to large-scale, high-throughput, multi-dimensional Genomics, Epigenomics, and Transcriptomics data with the main emphasis on elucidating and understanding human disease progression and development, which is further expected to translate to public health practice.

Recent News

February 13th, 2024

New Paper (Nat. Commun.)


Our cancer susceptibility genes paper has finally been accepted by Nature Communications. We have demonstrated a distinct class of cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study. Congratulations to Hui and Zeyang.

January 26th, 2024



Congratulations to our student Qixuan for being awarded the Shenzhen Bay Laboratory (SZBL) Director's Scholarship by Prof. Nieng Yan, Director of the SZBL.

January 25th, 2024

New Paper (Cell Discovery)

New Paper

Our RBBP6 collaborative work with Qi Xie’s Group has finally been accepted by Cell Discovery. We identified that E3 ligase RBBP6 is essential for glioblastoma stem cell maintenance and regulates MYC expression. Congratulations to Wenyan.

December 9th, 2023

National RNA Meeting


Dr. Li was invited to present in the 12th National Ribonucleic Acid (RNA) Academic Meeting in Shanghai.

November 11th, 2023

New Paper (Brief. Bioinformatics)


Our xQTLbiolinks paper has been accepted by Briefings in Bioinformatics. We described the xQTLbiolinks, as an end-to-end bioinformatic tool for mining and analyzing bulk and single-cell xQTL data. Congratulations to Dr. Ding and other lab members.

November 11th, 2023

New Paper (Nat. Commun.)


Our immune-response alternative polyadenylation has been finally accepted by Nature Communications. We have demonstrated the atlas of responsive 3′aQTLs (raQTLs), i.e., genetic variants associated with APA of target genes upon immune stimulations. Congratulations to Xuelian.