Computational and Disease Genomics Lab

● Our cancer susceptibility genes paper has finally been accepted by Nature Communications. We have demonstrated a distinct class of cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association study. Congratulations to Hui and Dr. Wang and also other lab members.

● Congratulations to our student Qixuan for being awarded the Shenzhen Bay Laboratory (SZBL) Director's Scholarship by Prof. Nieng Yan, Director of the SZBL.

● Our RBBP6 collaborative work with Qi Xie’s Group has been finally accepted by Cell Discovery. We identified that E3 ligase RBBP6 is essential for glioblastoma stem cell maintenance and regulates MYC expression. Congratulations to Wenyan. Cheers!

● Dr. Li was invited to present in the 12th National Ribonucleic Acid (RNA) Academic Meeting in Shanghai.

● Our xQTLbiolinks paper has been accepted by Briefings in Bioinformatics. We described the xQTLbiolinks, as an end-to-end bioinformatic tool for mining and analyzing bulk and single-cell xQTL data for discovering disease susceptibility genes. Congratulations to Dr. Ding and other lab members.

● Our immune-response alternative polyadenylation has been finally accepted by Nature Communications. We have demonstrated the atlas of responsive 3′aQTLs (raQTLs), i.e., genetic variants associated with APA of target genes upon immune stimulations. Congratulations to Dr. Ma and other lab members.

● Welcome Dr. Xixian Ma joins our lab as a Postdoctoral Associate, Dr. Ma received his PhD in Computational Biology from PICB (Partner Institute for Computational Biology) under the supervision of Prof. Shuhua Xu. Additionally, also we congratulate our student on being awarded the prestigious National Scholarship for Graduate Excellence.

● Our scQTLbase paper has been accepted by Nucleic Acids Research. We described an integrated human single-cell eQTL portal, which features 304 datasets across 57 cell types and 95 cell states. Congratulations to Dr. Ding, Qixuan, Lihai and other lab members!

● We received a new NSFC award for the next four years to study computational modeling of intronic polyadenylation in human cancers. Cheers!

● Xudong's abstract has been ACCEPTED as a platform (oral) presentation at the ASHG 2023 Annual Meeting. There are less than 10% of abstracts can be selected as oral presentations. Cheers!

● Dr. Li was invited to present at the Biological Data Science, AI&Medicine Workshop.

● We had a lab retreat in Shanghai and visit Dr. Ting Ni’s lab in Fudan Univerisity.

● Dr. Li was invited to give a talk in the Chinese Academic Conference on Tumor Biomarker.

● Congratulation our student Qixuan awarded the most prestigious Shenzhen Bay Principal's Award.

● Welcome visiting student Zhaozhao Zhao from Fudan University and HuiHui Yang from Central South University visit our lab.

● Welcome Dr. Zeyang Wang from University of Munich to join our lab as a postdoctoral fellow. His research focus on functional characterization of the regulatory activities of non-coding elements.

● Congrats! We co-organized the first Shenzhen bioinformatics symposium.

● Welcome Dr. Ting Zhang from Northwest A&F University to join our lab as a postdoctoral fellow. His research focus on single-cell method development.

● Our paper has been accepted by Nucleic Acids Research, we described the first atlas of intronic polyadenylation quantitative trait loci. Congratulations to Dr. Ma, Shumin and other lab members!

● Our collaboration paper with Dr. Jingyi Jessica Li from the University of California, Los Angeles has been accepted by Genome Biology. We found that PCA outperforms popular hidden variable inference methods for molecular QTL mapping.

● Our research is featured in Nature Spotlight on Precision medicine

● Welcome Ruilong Zhou from University of Chinese Academy of Sciences join our group. He is interested in developing deep learning and machine learning approaches to analyze single cell data.

● Our paper has been accepted in principle by STAR Protocols (Cell Press), Congratulations to Dr. Zou, Dr. Ding!

● Welcome Kewei Xiong join our group, his interest is focused on single cell algorithm development.

● Our paper have been featured on the cover of first issue of Quantitative Biology this year. Congrats to Dr. Zou and also Xiangli for the cover design.

● Dr. Li was invited to give a talk on Chinese Academic Conference on Tumor Biomarker.

● Welcome Prof. Jianzhong Su, Dr. Liangde Xu, Dr. Meng Zhou from Wenzhou Medical University and Professor Yushan Qiu from Shenzhen University visit our lab and give a talk in Shenzhen Bay Laboratory.